In the Pakistani entertainment industry, Mathira is working as an actress, model, host and, dancer. She is known for glamour, class, boldness and her item songs in various Pakistani and Bollywood movies.
In 2012 Mathira tied the knot with a Punjabi singer Farran J. Mirza. She kept the news of her marriage a secret from her fans for a year. On 4th September 2014 couple welcomed a baby boy named Aahil Rizvi. In 2018 Mathira wrote a note on her Instagram account announcing the end of her marriage.